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It forces a metabolic shift from oxidative phosphorylation to glycolysis and activates established pro-reprogramming signaling pathways, such as YAP/TAZ, which exacerbate inflammatory responses and fibrosis, thereby accelerating adverse ventricular remodeling [49, 101]

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While GHK-Cu has anti-inflammatory and wound-healing properties, direct clinical evidence for treating active acne breakouts is limited

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